Next-Generation DNA Sequencing Informatics PDF

Rating: (3 reviews) Author: ISBN : 9781936113873 New from $31.07 Format: PDF

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Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. Bioinformatics methods to support DNA sequencing have become a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. This book provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data. The book also provides extensive reference to best-practice bioinformatic methods for the most commonly used NGS technologies and applications. The book also includes reference to, and guidance, on the setup and use of essential software for NGS data analysis. This is the first book of its kind to address the informatics needs of scientists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies.

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• Product Details
• Table of Contents
• Reviews

• Hardcover: 256 pages
• Publisher: Cold Spring Harbor Laboratory Press; 1 edition (January 1, 2013)
• Language: English
• ISBN-10: 1936113872
• ISBN-13: 978-1936113873
• Product Dimensions: 10.1 x 7.2 x 0.9 inches
• Shipping Weight: 1.6 pounds (View shipping rates and policies)

Next-Generation DNA Sequencing Informatics PDF

This book is an embarrassment - it is little more than a hodge-podge of information collected from random corners of the internet.

Most of the people that were recruited to write it (it is a collection of works by many individuals) are not qualified to have written the chapters that they authored. The editor simply looked for individuals all at the same institute (NYU) that were asked to produce a chapter or two. These two factors lead to an overall incoherence - some chapters are full with pointlessly complex mathematical formulas and theorems (spanning pages) that provide no insight whatsoever into how the methods actually operate in practice. Then the book may switch with no warning to command line programs then later chapters are simply printouts of a guides that are already on the internet and are filled with instructions of the sort of "click here" then "click there".

Fundamentally the book lacks any actionable advice that would help a scientist make useful decisions. Heh, only if assembly was as easy as running velvet five times then picking the results with the largest N50.

The flaws of this book are so numerous and so obvious that it is too painful to enumerate them and indicate a complete lack of editorial oversight.

Far better information can be found in any review article published in just about any journal. In fact I dare to say a ten minute google search on any topic would give a user better advice than what is found in this book.

By bioinfo

I purchased this book hoping to learn some in-depth information about NGS and specifically RNAseq. It is basically an overview of some information related to bioinformatics for NGS data, but rarely dips beneath surface level information. Perhaps it could be considered a decent overview of the variety of NGS informatics topics for those who are unfamiliar with the technology. However, this book gives little insight as to how to produce an actual real world analysis of NGS data-- you will have to go further than this book for that. I did like reading it at some points to get an overall feel for the technology, but if you are looking for in-depth details or a "how to" for analysis, you'd be best advised to find further information, perhaps on the web and through journal articles. Since the software used in the real world for NGS is advancing so quickly, some of the information in the book already seemed a little dated. Overall, if one were very new to NGS analysis and wanted an overview of related topics, this could be an OK option.

By Kaittenage