Means to an End: Apoptosis and Other Cell Death Mechanisms PDF

Rating: (2 reviews) Author: Douglas R Green ISBN : 9780879698881 New from $30.84 Format: PDF

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One million cells in our bodies die every secondthey commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

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• Product Details
• Table of Contents
• Reviews

• Paperback: 250 pages
• Publisher: Cold Spring Harbor Laboratory Press; 1 edition (October 29, 2010)
• Language: English
• ISBN-10: 0879698888
• ISBN-13: 978-0879698881
• Product Dimensions: 0.5 x 6.5 x 9 inches
• Shipping Weight: 15.2 ounces (View shipping rates and policies)

Means to an End: Apoptosis and Other Cell Death Mechanisms PDF

This is a short, well-written book covering a specific scientific topic. It's up-to-date (2011), it's got a distinct visual style, and it's very accessible to someone with a basic biology background.

By F. Gibbons

Sheds light on a murky understanding [on my part] of cell death issues.
This is an informative and well written read.

By K. Bailey